- A member of a high-risk groups (Native Americans, Latinos, Asian-Americans, and African-Americans),
- Lack of activity – being obese – resistance to insulin
- Disturbance of normal physiologic function of the body - hormones
- genetic defects in the human sixth chromosome abnormalities on HLA
- Older people experience degenerative of the organ including pancreas – less production of insulin can lead to DM
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